Gastroprotective Effect of Dalargin in Gastropathy due to Treatment with Nonsteroid Antiinflammatory Drugs

We studied the effect of dalargin and its analogue [Dala] 2 -leu-enkephalin on the gastric mucosa in indomethacin-receiving animals. Indomethacin treatment was followed by severe injury to the gastric mucosa, decrease in proliferative activity of the epithelium, and stimulation of free-radical processes in gastric tissues. Dalargin significantly decreased the area of erosive and ulcerative lesions, had a normalizing effect on proliferation of epithelial cells, and reduced the degree of oxidative stress. Administration of [Dala] 2 -leu-enkephalin did not improve the state of the gastric mucosa.