A Review of Biomedical Poly(lactic acid) Modification Research Progress

Polylactic acid(PLA) is at present one of the most promising biodegradable polymers and has a wide range of applications.It has become one of the most important biomedical materials.But the PLA also has many disadvantages,which limits its application in the medicine field.In this paper,the strong hydrophobicity,poor cellular affinity,poor mechanical properties,aseptic inflammation reaction resulted from local accumulation of lactic acid produced by degradation products,lacking series products whose repair,degradation and absorption speed cannot well matched their cell proliferation and tissue repair speed,high cost,poor hole forming performance of homopolymer are reviewed.Summarized the scheme at home and abroad in recent years in view of the above various defects made,and the direction of research and development of PLA medical modification are discussed.Besides,the improvements made in recent years for each of the above defects are summarized.At last,the research and development orientation on PLA medical modification are prospected.