Analysis and digital 3D modeling of long-range fourier-domain optical coherence tomography images of the pediatric subglottis
2014
In neonatal and pediatric patients who require long-term endotracheal intubation, the subglottic mucosa is most
susceptible to injury from the endotracheal tube. At present, there is no diagnostic modality to identify early signs of
subglottic mucosal pathology. Fourier-domain optical coherence tomography (FD-OCT) is a minimally-invasive
imaging modality which acquires high-resolution, 3D cross-sectional images of biological tissue. FD-OCT of the
neonatal and pediatric airways was conducted to evaluate subglottic microanatomy and histopathologic changes
associated with prolonged intubation.
FD-OCT of the larynx, subglottis and proximal trachea was conducted in pediatric and neonatal patients. OCT image
sets were analyzed by anatomic categorization (airway level), tissue segmentation and mucosa micrometry in MATLAB.
Subsequently, OCT data sets were rendered into digital 3D airway models in Mimics software. We report original
methods for subglottic OCT image processing and analysis.
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