Study of Pattern of Pediatric Dermatoses in a Tertiary Care Centre In Jammu Division of Jammu and Kashmir.

Introduction: Diabetic nephropathy, which is characterized by microalbuminuria, subsequent macroalbuminuria, & declining glomerular filtration rate, is a single most frequent cause of end stage renal disease in the world. Reduced renal function is associated with increased incidence of cardiovascular morbidity and mortality. Microalbuminuria is the best available test for screening of Diabetic Kidney Disease, but it is imprecise. Cystatin C is a peptide of 122-amino acid and was first investigated as marker of GFR. It is the product of a “housekeeping” gene expressed in all nucleated cells and is produced at a constant rate. It is freely filtered at the glomerular membrane and is reabsorbed and catabolized by renal tubular cells. It has potential advantages over creatinine when estimating glomerular filtration rate in that its production is not dependent on muscle mass. In addition, it is unaffected by age, fever, or exogenous agents. Material & method: The study has been conducted on 150 diagnosed & clinically established patients of Diabetes mellitus (type-I & type-II) who attended OPD and wards of Medicine, J.L.N. Medical College and Associated group of Hospitals, Ajmer. Subjects were categorized in various chronic kidney diseases (CKD) staging viz CKD-1, CKD-2 & CKD-3. Anthropometric measurements and biochemical estimations were performed. Results and discussion: Serum Cystatin C values were found to be significantly increased in subjects of CKD stage 1 (0.80 ± 0.14 mg/l), and serum creatinine level found to be increased in patients of CKD stage 3 (1.30 ± 0.41 mg/l) as compared to control subjects. Conclusion: Cystatin C discloses earlier decline of GFR in subjects of CKD. Early detection of renal function decline can optimize detection of cardiovascular risk & help in clinical management to prevent complications.