Aphthous stomatitis in COVID-19 patients: Case-series and literature review.

We have read with great interest the review of Iranmanesh et al. (2020) on oral manifestations of coronavirus diseases (COVID-19) which demonstrated the emergence of aphthous-like lesions in 16 cases thus suggesting that neutrophil chemotaxis, stress, and immunosuppression could be causal pathways for this condition to appear in COVID-19 patients.1 As a result of this, we aim to report according to the CARE guidelines, the characteristics of 21 laboratory-confirmed COVID-19 patients with aphthous stomatitis.2 We have also performed an updated literature search in Ovid MEDLINE, EMBASE, Cochrane Library, Epistemonikos from inception until November 26th, 2020 with a combination of keywords (COVID-19 or SARS-CoV-2) and aphthous.