Angiotensin-(1–7) synergizes with colony-stimulating factors in hematopoietic recovery

Purpose Angiotensin (1–7) [A(1–7)] is a bioactive peptide of the renin angiotensin system that stimulates the number of bone marrow progenitors and hematopoietic recovery after myelosuppression. We evaluated the combination of A(1–7) with colony-stimulating factors, Neupogen and Epogen, on bone marrow progenitors and the recovery of circulating formed elements following chemotherapy.