An updated phylogeny of the Alphaproteobacteria reveals that the parasitic Rickettsiales and Holosporales have independent origins

The Alphaproteobacteria form one of the most abundant groups of bacteria on Earth, and one that is closely linked to all complex forms of life. Many bacteria within this class live inside the cells of other organisms. For example, mitochondria – the powerhouses of animal, plant and other eukaryotic cells – evolved from bacteria within this group. Other alphaproteobacteria act as parasites or beneficial symbionts within cells. The history of life on Earth can be thought of as a tree, with each branch representing the evolution of a new species from a common ancestor. But for many bacteria, the earliest stages of their evolutionary history are so tangled and complex that their origin remains largely unknown. For example, efforts to study the earliest history of the Alphaproteobacteria have been plagued with errors and artefacts. The extreme variation in the genetic sequences of different bacteria in the group make it particularly challenging to uncover relationships between the species. To overcome this problem, Munoz-Gomez et al. focused on a set of 200 genes that occur in all alphaproteobacteria, and used a range of strategies to reduce potential errors in the data. The results propose a new general structure for the evolutionary tree of the Alphaproteobacteria. This shows that two groups of alphaproteobacteria that were thought to be closely related to each other – the parasites Rickettsiales and Holosporales – are unrelated. Instead, these groups evolved independently from different free-living alphaproteobacteria. The abundance and diversity of the Alphaproteobacteria means that the improved understanding of their evolutionary origins could influence the work of a wide range of scientists. Further research could help to shed light on how parasitic bacteria interact with the cells they invade; reveal how bacteria evolved certain abilities, such as the ability to photosynthesize; and uncover the precise origin of mitochondria.