Establishment of Anti-oxidation Platform Based on Few-Layer Molybdenum Disulfide Nanosheet-Coated Titanium Dioxide Nanobelt Nanocomposite

Abstract The nanozyme-based antioxidant system could protect normal cells from oxidative stress due to their reactive oxygen species (ROS) scavenging activity and good chemical stability. However, its use is limited for practical in vivo applications due to the high cost and poor biocompatibility (low catalytic efficiency). Herein, MoS2 decorated on TiO2 nanobelts (MoS2@TiO2) was prepared for antioxidation applications. The as-prepared MoS2@TiO2 heterostructure with 50 wt% MoS2 showed the highest efficient catalase activity and superoxide dismutase (SOD) activity under normal physiological conditions. The composite was superior to its single component in terms of enhanced dispersibility and catalytic performance resulting from the higher surface specific area and more exposed active sites. MoS2@TiO2 was not only confirmed to have good in vitro and in vivo biocompatibility but can also effectively eliminate the endogenous excessive accumulation of ROS caused by oxidative stress using the fibroblast cell (L929) line as a model. Further experiments confirmed that in the established mouse oxidative stress model, MoS2@TiO2 can quickly restore the ROS to a normal level in the oxidative stress site of the mouse. These results indicated that MoS2@TiO2 enzyme-like nanomaterials can provide a huge therapeutic potential in future antioxidant defence applications.