Clinical effects of Nedaplatin,Tegafur Gimeracil Oteracil Potassium capsule combined with three-dimensional conformal radiotherapy in elderly patients with locally advanced non-small cell lung cancer

Objective: To investigate the clinical effects and safety of Nedaplati,Tegafur Gimeracil Oteracil Potassium capsule combined with three-dimensional conformal radiotherapy in elderly patients with locally advanced non-small cell lung cancer.Methods: A total of 50 elderly patients with locally advanced non-small cell lung cancer that were treated in our hospital from January 2010 to January 2011 were selected and randomly divided into control group(only three-dimensional conformal radiotherapy group)and observation group(Nedaplatin,Tegafur Gimeracil Oteracil Potassium Capsule combined with three-dimensional conformal radiotherapy group)with 25 cases in each group,then the total effective rate,clinical benefit rate,progression-free survival,one-year survival rate and adverse reactions of two groups were compared.Results:The total effective rate and clinical benefit rate of observation group were 88.00% and 96.00%,and they were significant higher than 56.00% and 84.00% of observation group,progression-free survival time of the observation group was(17.5±1.8)months,significant longer than(11.9±1.3)months of the control group,one-year survival rate was 72.00%,and it was higher than 48.00% of control group(P0.05).Hematological toxicity of the observation group was higher than that of control group(P0.05).However,the rates of radioactive esophagitis and radiation pneumonitis of two groups was not significantly different(P0.05).Conclusion:The clinical effects and safety of Nedaplatin,Tegafur Gimeracil Oteracil Potassium Capsule combined with three-dimensional conformal radiotherapy in the treatment of elderly patients with locally advanced non-small cell lung cancer is better,and the adverse reactions is tolerable.