010 — (BOR0176) PER2, PER3, and clock polymorphisms are not associated with juvenile myoclonic epilepsy in a sample of the Brazilian population

Sao Paulo (UNIFESP), number 0164/12. Results: The two-way ANOVA with repeated measures revealed significant effects of time [F (2,36) = 33.99, p b 0.001], prenatal treatment [F (1,36) = 4, 32 p b 0.05], and postnatal treatment [F (1,36) = 113.87, p b 0.001] and interaction prenatal treatment × postnatal treatment [F (1,36) = 5, 80, p b 0.05], time × postnatal treatment [F (2,36) = 33.54, p b 0.001], and prenatal treatment × postnatal treatment × time [F (2,36) = 3.28, p b 0.05]. Duncan's test revealed that the behavioral sensitization to AMP occurred in the 3rd day injection of SAL or AMP (5th day of treatment), with a significant increase in locomotion in the AMP-treated groups (3rd day N 1st day). Importantly, the prenatal treatment with POLY:IC potentiated behavioral sensitization to AMP. Discussion/conclusions: Our results indicate that prenatal POLY:IC administration potentiated AMP-induced behavioral sensitization and support the observation that patients with schizophrenia present an increase in the prevalence of substance use disorders.