The ultrasonic and clinical features of Kimura′s disease

Objective To investigate the clinical features of Kimura′s disease. Methods The clinical characteristics, laboratory tests, genetic testing, the features of imaging, bone marrow biopsy and pathology of Kimura′s disease were retrospectively analyzed. Results Laboratory tests showed that white blood cell count was 11.65×109/L, eosinophil count was 3.12×109/L, the percentage of eosinophil was 35.6%.Erythrocyte sedimentation rate was 32mm/h, C-reactive protein was 20 mg/L.The ultrasound showed that there were several beaded lymph node which were adjacent to blood vessels on the left neck, and the cortical thickened.Thoraco-abdominal CT and bronchoscopy revealed no obvious abnormalities.Bone marrow biopsy showed myeloid and erythroid hyperplasia.A number of beaded lymph node integration into group, with the surrounding tissue adhesion.Histopathological examination showed that lymphoid hyperplasia with follicular hyperplasia and diffuse eosinophilic infiltration on interfollicular.Immunohistochemical staining showed CD3, CD20, CD21 and 80% of Ki-67 of follicular area were positive, Bcl-2 was negative. Conclusions Kimura′s disease is a chronic inflammatory disease characterized by lymphadenia, with high peripheral blood eosinophil count and serum immunoglobulin E (IgE). Its diagnosis relys on physical examination, laboratory tests and imaging findings.Histopathological examination can confirm the diagnosis. Key words: Kimura′s disease; Lymphoid tissue; Granulocytes; Diagonsis