Coprocessed Excipients in Direct Compression and Their Prospect

With the advancement of tablet manufacturing process,the demand of excipients with improved functionalities,mainly in terms of flow and compression properties,has increased.Coprocessed excipients are a mixture of two or more existing excipients at subparticle level,offer substantial benefits of the incorporated excipients and minimize their drawbacks.These multipurpose excipients have dramatically reduced the number of incorporating excipients in the tablet.The potential advantages and limitations of coprocessing and coprocessed excipients,various coprocessed excipients for direct compression available in the market and the prospects of coprocessed excipients were discused in this review.