Withanolides from Physalis angulata L.

The compounds (17S,20R,22R,24R,25S)-5β,6β:20,24-diep­oxy-4β,25-dihy­droxy-1-oxowith-2-en-26,22-olide and (20R,22R)-5α,14α,20-Trihy­droxy-1-oxo-6α,7α-ep­oxy­witha-2-enolide were isolated from a chloro­form extract of the aerial parts of Physalis angulata L. (Solanaceae). Two products were isolated from the chromatographic separation extract. Compound I corresponds to physangulide B chloro­form monosolvate, C28H38O7·CHCl3, while compound II is 14α-hy­droxy­ixocarpanolide, C28H40O7. In the two mol­ecular structures, the conformation of the steroid part (rings A, B, C, D) does not differ. In both crystals, mol­ecules are linked by inter­molecular O—H⋯O hydrogen bonds along the c-axis direction and form a two-dimensional network parallel to the ac plane. The absolute configuration was determined from X-ray diffraction data.