A New Monoterpene from the Rhizomes of Alpinia galanga and Its Anti-Vpr Activity.

A new menthane-type monoterpene, alpigalanol ( 1 ), together with four known terpenes ( 2 - 5 ) were isolated from the ethyl acetate soluble fraction of the 70% ethanol extract of the Alpinia galanga rhizomes. The structure of 1 was determined by spectroscopic analyses, including 1D- and 2D-NMR. The extract of the A. galanga rhizomes and all isolated compounds ( 1 - 5 ) possessed Vpr inhibitory activities against the TREx-HeLa-Vpr cells at a concentration of 1.25 μM without showing any cytotoxicity.