The extraction, separation and purification of alkaloids in the natural medicine

In this paper, I will have natural medicine alkaloids extraction, separation and purification methods for a talk, the presence of alkaloids of natural medicine are in the form of free or salt alkaloids, so inorganic acidic water can be used to extract in order to have alkaloids organic acids replaced with inorganic acid salt and increase its solubility; The free alkaloids or salt both can be dissolved in methanol, ethanol, we can use heated alcohol under reflux extraction or ultrasonic alcohol extraction; and most of the free alkaloid is lipophilic, also can use heated alcohol under reflux to extract free alkaloids with the organic solvent such as chloroform, benzene, ether and so on. Most obtained alkaloids by extracting are mixture, according to the alkaloids class, basicity, solubility differences and the special functional group of alkaloids to separate the alkaloid mixture. Then the separated monomer detectable.