Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [11C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [11C](R)-PK11195

Kentaro Hatano,Katsuhiko Sekimata,Takashi Yamada,Junichiro Abe,Kengo Ito,Mikako Ogawa,Yasuhiro Magata,Jun Toyohara,Kiichi Ishiwata,Giovanni Biggio,Mariangela Serra,Valentino Laquintana,Nunzio Denora,Andrea Latrofa,Giuseppe Trapani,Gaetano Liso,Hiromi Suzuki,Makoto Sawada,Masahiko Nomura,Hiroshi Toyama

Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [11C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [11C](R)-PK11195

2015

Objective We report synthesis of two carbon-11 labeled imidazopyridines TSPO ligands, [11C]CB184 and [11C]CB190, for PET imaging of inflammatory process along with neurodegeneration, ischemia or brain tumor. Biodistribution of these compounds was compared with that of [11C]CB148 and [11C](R)-PK11195.

Keywords:

Neurodegeneration
Positron emission tomography
Translocator protein
Internal medicine
Benzylidene compounds
Radiosynthesis
In vivo
Cardiology
Biodistribution
Biochemistry
Medicine
Pathology
Ligand

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