A Review on PPARγ- A Novel Therapeutic Target for Alzheimer's Disease

Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder with dementia in the elderly and the number of affected individuals after the age of 60, rising from a prevalence of 1% at age 60 to 40% for individuals over 85 years old. The brain areas involved in memory include the cortex, hippocampus. The AD brain pathology is characterized by deposits of amyloid-β (Aβ) peptides and neurofibrillary tangles (NFT) characterize by signs of a chronic inflammatory process. β -APP metabolism is occur by 2 pathways and , .