Niveles de dolor y tolerancia a la biopsia endometrial, con ibuprofeno

Objective: To compare the levels of pain and tolerance to the endometrial biopsy with the Novaks cureta (Rigid), in patients who receive Ibuprofen 800mg versus placebo, 30 to 45 min. before the procedure. Material and Methods: This is a double blind, randomized, comparative clinical trial. We included 25 patients per treatment group, one group received two capsules of Ibuprofen of 400mg PO and the other one, two capsules of placebo PO according to the sequence. Both groups were compared according to filial data, gynecological and obstetric history, the reason for the endometrial biopsy and finally the valuation of his pain experience and tolerance to the procedure. Results: The populations are comparable to each other. When evaluating the variable pain, there was statistically significant difference between values of pain in group that received Ibuprofen (Median 45mm) and values in group that received placebo (Median 65mm) with p=0.0137. There was not statistically significant difference in the variable tolerance between group that received Ibuprofen (Median 37mm) and group that received placebo (Median 53mm) with p=0.23. Conclusion: We conclude that the use of 800mg of oral Ibuprofen 30 to 45 minutes before the endometrial biopsy in patients older than 44 years diminishes their pain experience during the procedure. ( Rev Med Hered 2003; 14: 122-127 ).