Occupational medicine monitoring of workers exposed to benzene

Based on the present level of perception of the benzene biotransformation, the influence of reactive metabolites on the haematopoetic system - maintaining low MAK rates of 5 mg/m3 and below them - is presented. Consequences for the rate of the biological exposition test utilized at present result from this statement. The importance of a regular SCE determination in circulating lymphocytes, of the longtermed examination of possible damages of sperm and the differentiated analysis of individual kinds of lymphocytes, incl. of the cell-mediating immunity is emphasized besides the performance of a regular supervision of the external exposition, i.e. by means of personal dosimeters. To clarify the benzene influence, the research should be orientated on the damages of the cytoskeleton and the stroma cells within the haematopoetic system.