Finally, the beginnings of molecular biology

the equilibrium between active native trypsin and inactive denatured trypsin. Mirsky's sabbatical year led to a classical paper, written with L. Pauling, formulating a general theory of protein structure and of folding and unfolding 6. Meanwhile, Anson used the time to work on carboxypeptidase, which he had just crystallized in Northrop's laboratory. John Northrop 7, possessing a doctorate in chemistry, had joined Jacques Loeb at the Rockefeller Institute in 1915. Loeb, who had headed the Laboratory of General Physiology at that Institute since 1910, believed that chemistry and physics would explain many biological phenomena. In 1913, Loeb had hired Moses Kunitz as a research assistant and Kunitz became the skilled executor of Loeb's experiments on the binding of ions to proteins. Kunitz, who at the age of 22 had fled the Czar's police in 1909, attended college and graduate school at