Synthesis and Biological Evaluation of Pyrido(2,3‐b)pyrazine and Pyrido(2,3‐b)pyrazine N‐Oxide as Selective Glycine Antagonists

Alfredo Cugola,Daniele Donati,M. Guarneri,Fabrizio Micheli,Andrea Missio,Angelo Pecunioso,Angelo Reggiani,Giorgio Tarzia,V. Zanirato

Synthesis and Biological Evaluation of Pyrido(2,3‐b)pyrazine and Pyrido(2,3‐b)pyrazine N‐Oxide as Selective Glycine Antagonists

2010

Alfredo Cugola
Daniele Donati
M. Guarneri
Fabrizio Micheli
Andrea Missio
Angelo Pecunioso
Angelo Reggiani
Giorgio Tarzia
V. Zanirato

Abstract Pyrido[2,3-b]pyrazines and pyrido[2,3-b]purazines-N-oxides have been synthesized and evaluated for in vitro/in vivo antagonistic activity at the glycine site on the NMDA receptor

Keywords:

Glycine Antagonists
Oxide
Pyrazine
Organic chemistry
Chemistry
biological evaluation

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