Tumor bombesin analog loaded long-circulating and pH-sensitive liposomes as tool for tumor identification

Abstract Long-circulating and pH-sensitive liposomes trapping 99m Tc-HYNIC-βAla-bombesin (7–14) (aSpHL- 99m Tc-BBN (7–14) ) were successfully prepared. Biodistribution studies and scintigraphic images were performed in Ehrlich tumor-bearing Swiss mice. This system showed high accumulation in tumor tissue with high tumor-to-muscle ratio. Therefore, aSpHL- 99m Tc-BBN (7–14) could be considered as a potential agent for tumor diagnosis.