Análise Citotóxica e Mutagênica do Extrato Aquoso de Maytenus guya- nensis Klotzsch Ex Reissek (Celastraceae) Chichuá (Xixuá) Amazônico Analysis cytotoxic and mutagenic the Aqueous Extract of Maytenus guyanensis Klotzsch Ex Reissek (Celastraceae) Chichuá (Xixuá) Amazon

The Maytenus genus is the largest in the Celastraceae family this comprises about 225 species. Maytenus guyanensis is an endemic tree of dry land in the Amazon, and known as chichua, xixua, chuchahuasi, chucchu Huashu, chuchuasi and chuchasha. Its roots and stems are used as analgesic, anti-inflammatory, aphrodisiac, muscle relaxant, antirheumatic, antidiarrheal and anti-interference is also indicated for the treatment of arthritis, impotence, flu, bronchitis, hemorrhoids and cancer. This study aimed to perform a cytotoxic and mutagenic analysis of aqueous extract of M. guyanensis. The methods used were: mitotic index, germination of meristems and analysis of micronucleus in Allium cepa. It was found that the aqueous extract of M. guyanensis bark at concentrations of 3.85 and 38.5 mg / mL does not presented cytotoxic and mutagenic action, and also acted as anticitotoxico and antimutagenic. The treatment of 77mg/mL demonstrated to have effects cytotoxic and anticitotoxica in the presence of paracetamol, this concentration showed no mutagenic and antimutagenic action. The concentration of 192mg/mL was identified action cytotoxic and mutagenic. The study demonstrated the safety cytotoxic and mutagenic of use traditional of M. guyanensis. Future studies are indicated in vitro (lymphocytes) and in vivo (mice) for a better understanding of the physiological effects of extracts and isolated compounds for better conclusions on the safe use of the same, and even the development of a herbal drug or taking this species as raw material.