Efficient Synthesis of 2,3,4-TrisubstitutedQuinolines via Friedländer Annulation with NanoporousCage-Type Aluminosilicate AlKIT-5 Catalyst

2-Aminoaryl ketones undergo smooth Friedlander condensation/annulation with α-methyleneketones on the surface of nanoporous aluminosilicate catalyst to afford the corresponding quinoline derivatives in good yields with high selectivity due to its high surface area, large pore volume, and high acidity. The use of highly acidic and reusable AlKIT-5 catalyst makes the Friedlander annulation simple, convenient, and practical.