Oxazolidinones as novel human CCR8 antagonists
2007
Abstract High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 ( 1a ), are described.
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