Papel del HLA en la patogenia de los aneurismas de aorta abdominal

Summary Introduction Recently, changes in metaloproteinases matrix has been described in abdominal aortic aneurysms (AAA). This changes are due to inflamatory processes that could be implicated in their pathogenesis. There are few reports that study autoinmunity implication in the pathogenesis of this pathology. Objective To study the HLA class II and III complex to evaluate the implication of autoinmunity in the AAA. Patients and methods HLA class II and HLA class III corresponding to tumor necrosis factor and its promoter were typed in a group of 72 patients with an AAA. These results were compared with a group of 380 healthy volunteers as control group. Results HLA-II: HLA-DR4*401 was more frecuent in AAA than in control group (12.5% vs 5.2% p 0.02 OR 2.59). There were not any other difference between both groups. TNF: TNF α 4 β 5 was more frecuent in AAA group than incontrol group but statistical differences were not encountered (p= 0.055). There were not any difference in the frecuencies of TNF promoters. Haplotypes: HLA-DR3-TNF α 2 β 3 ancestral haplotipe was more frecuent in AAA than in control group (16.6% vs 8.4%, p= 0.03, OR = 2.17). Conclusion The relationship encountered between HLA-DR4*401 and ancestral haplotype HLA-DR3-TNF α 2 β 3 , that is associated with other autoinmune processes, suggest that autoinmunity could play an important role in the pathogenesis of abdominal aortic aneurysms.