An Efficient Synthesis of Isoindolo[2,1-a]quinoline Derivatives via Imino Diels-Alder and Intramolecular Diels-Alder Reactions with Furan
2007
The straightforward synthesis of new isoindolo[2,1-a]quinoline derivatives from 2,4-disubstituted 1,2,3,4-tetrahydroquinolines bearing a furan fragment via the intramolecular Diels-Alder reaction is reported. The synthesis of key precursors was realized with excellent levels of diastereoselectivity either by Povarov reaction or by a multicomponent condensation approach.
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