HCT for Germ Cell Tumors

The use of high-dose chemotherapy with autologous hematopoietic cell transplantation is well established as a potentially curative approach to patients with relapsed or refractory disease after initial cisplatin-based chemotherapy. The use of tandem transplant with high-dose carboplatin and etoposide conditioning in this setting has been a standard in the United States based on the large experience from Indiana University. Ongoing randomized trials seek to confirm this approach.