On the etiology of epileptic seizures in children of the first year of life

: The paper presents the analysis of unfavourable ante- and intranatal factors as well as the data of neurosonography of 109 children with the fits during the first year of life and of 58 children with hypoxic-ischemic encephalopathy without convulsions. The high degree of the correlation was found between complications of the first half of pregnancy and the disturbances of growth and development of a child. Frequency of a trauma in the course of a delivery correlated with frequency of asphyxia. A persistence of a germinative matrix and signs of functional immaturity of the brain suggested the important role of both focal and multifocal cerebral dysplasias in the genesis of epileptic fits at the early stages of ontogenesis. In children with nonmalignant neonatal and idiopathic fits there were some nonvisualized cortical disorders that became pronounced under hypoxic-dysmetabolic conditions in the first case and during a period of the following maturation of axon-dendritic bounds and of the increase of neuronal activity in the second case.