Man-made load of industrial environment and its impact on human microbiota

People are exposed to a significant amount of man-made hazards upon contact with technological systems, and foundry engineering industrial sites belong undoubtedly to such systems. Foundry shops are characterized by high noise and temperature thresholds that affect the human body. Unsatisfactory condition of the air is considered to be an acute problem in foundry engineering. In this connection, the state of air and its composition change, which can certainly affect health of workers, and the latter may be seen in the respiratory, cardiovascular, nervous systems, and digestive organs functional changes. However, up to date, the effect of health hazards of foundry engineering on the microbiocenosis of human intestine remains poorly studied. The paper apprizes the microbiota of human large intestine being exposed to integrated effects of foundry engineering factors. A structural change of the intestinal coenotype accompanied by a change of absolute dominants and opportunistic microorganisms appearance is established. Intestinal microbiocenosis disorder is accompanied by a high detectability of parasitic protozoa Blastocystis spp. in the sampling material. The obtained blastocyst isolates have pathogenic properties of varying degree of manifestation, which indicates their unequal etiological significance in the development of the pathological process. The isolated strains of protozoa have a high anti-interferon activity characterizing their persistent properties. This characteristic brings along the displacement of normal symbionts by blastocysts and colonization of the intestinal mucous membranes with these protozoa.