Controlled release formulation to avoid misuse

2009 
A solid composition for oral administration of at least one pharmaceutically active agent, comprising: (a) a first layer comprising a first population of controlled release microparticles having a pharmaceutically active agent disposed therein; (B) a second layer comprising a pharmaceutically active agent disposed therein; and (c) a superabsorbent material disposed within the first layer, the second layer, or both the first layer and the second layer, wherein the composition, (i) when intact and exposed to a aqueous environment, initially, the pharmaceutically active agent disposed in the second layer is released to the pharmaceutically active agent disposed in the first layer, and (ii) when triturated faster rate and exposed to an aqueous environment, the superabsorbent material it swells to create a hard gel that traps the microparticles, after which the hard gel, microparticles or both the hard gel as the microparticles enables controlled release of at least the pharmaceutically active agent disposed within microparticles.
    • Correction
    • Source
    • Cite
    • Save
    • Machine Reading By IdeaReader
    0
    References
    0
    Citations
    NaN
    KQI
    []