Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis

Jiyuan Zhang,David Dominguez-Sola,Shafinaz Hussein,Ji Eun Lee,Antony B. Holmes,Mukesh Bansal,Sofija Vlasevska,Tongwei Mo,Hongyan Tang,Katia Basso,Kai Ge,Riccardo Dalla-Favera,Laura Pasqualucci

Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis

2015

Jiyuan Zhang
David Dominguez-Sola
Shafinaz Hussein
Ji Eun Lee
Antony B. Holmes
Mukesh Bansal
Sofija Vlasevska
Tongwei Mo
Hongyan Tang
Katia Basso
Kai Ge
Riccardo Dalla-Favera
Laura Pasqualucci

Two studies demonstrate that the methyltransferase KMT2D, which is recurrently mutated in several types of human B cell lymphoma, suppresses tumorigenesis by altering the epigenetic landscape of B cells; Kmt2d deletion in mice perturbs normal B cell development.

Keywords:

Immunology
Epigenetics
DNA methylation
Cell growth
B-cell lymphoma
Carcinogenesis
Cancer research
Germinal center
Methyltransferase
B cell
Biology
Tumor suppressor gene
Follicular lymphoma
Diffuse large B-cell lymphoma

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