Characterizing Posterior Fossa Syndrome: A Survey of Experts

Abstract Background Despite recent efforts, disagreement remains amongst front-line clinicians regarding the operational definition of a syndrome commonly referred to as Posterior Fossa Syndrome (PFS) and/or Cerebellar Mutism Syndrome (CMS). Methods This study surveyed experts in the clinical care of children with posterior fossa tumors to identify trends and discrepancies in diagnosing PFS. Results All surveyed professionals conceptualized PFS as a spectrum diagnosis. The majority agreed mutism is the most important symptom for diagnosis. However, results highlighted ongoing discrepancies related to important features of PFS. Conclusions Greater PFS conceptual alignment amongst providers is needed to formulate specific diagnostic criteria that would further research and clinical care. The authors propose preliminary diagnostic criteria for PFS that require refinement through careful clinical characterization and targeted empirical investigation.