Cell Growth and Protein Expression Kinetics

Introduction Batch-Culture Kinetics Experimental Data Unstructured Kinetic Models Comparison of Model Simulations with Experimental Data Continuous-Culture Kinetics Experimental Data Structured Kinetic Models Cell-Cycle Models Segregated Models Fed-Batch and Perfusion Cultures Optimization of Monoclonal Antibody Production Model Simulations for Fed-Batch Cultures Suboptimal Growth-Associated Production Kinetics Conclusions Acknowledgments Nomenclature Bibliography Keywords: physiology; induction; promoters; enhancers