Reduced Erythrocyte Carbonic Anhydrase Activity by Swietenia Macrophylla Seeds in Diabetic Rats

Background: We have previously reported that the CA activity is associated with advance glycation end product in insulin resistance condition. Our earlier report also revealed that Swietenia macrophylla effectively reduces the blood glucose levels in streptozotocin induced diabetic rats. Aim: The present study aims to find out if there is any effect of these plant extract on CA activity in Diabetic rat model. Materials and Methods: Streptozotocin was used to induce diabetes except in the control group.The activities of the Carbonic anhydrase in plasma and other biochemical parameters were estimated using standardized methods. Results: Our Results demonstrate the erythrocyte CA activity is positively correlated with the blood glucose as well as total cholesterol, triglyceride, LDL cholesterol levels. There is reduction of CA activity under the effect of these extract along with effective lowering of blood glucose and the above lipid parameters. Conclusions: The extract of Swietenia macrophylla seeds effectively inhibits erythrocyte CA activity and has potential for use to control Diabetes Mellitus and prevent complications.