Pantothenate kinase-associated neurodegeneration: A classical case report and literature review

SUMMARY Pantothenate kinase-associated neurodegeneration (PKAN) is a rare neurodegenerative disease characterized by progressive extrapyramidal dysfunction and iron accumulation in the basal ganglia. The classic sign in neu-roimaging of “eye of the tiger” is seen on T2-weighted magnetic resonance imaging scan. We present a classic case of the disease in a child who starts with motor symptoms at 5 years old and was studied at the Instituto de Ortopedia Infantil Roosevelt, with typical neuroimaging and confirmation of the mutation by molecular study.KEY WORDS:Pantothenate kinase-associated neurodegeneration, neurodegeneration, dystonia, spasticity, neuroimaging with “eye of the tiger” (MeSH). Recibido: 5/03/15. Aceptado: 31/08/15. Correspondencia: Heidy Gomez Naranjo: heidyjohannag@gmail.com (1) Pediatra, Neurologa Pediatra, Universidad Militar Nueva Granada. (2) Pediatra, Neurologa Pediatra, jefe del Programa de Posgrado en Neurologia Pediatrica, Universidad Militar Nueva Granada, Hospital Militar Central. Neurologa Pediatra, Instituto de Ortopedia Infantil Roosevelt.(3) Residente de III ano de Neurologia Pediatrica, Universidad Militar Nueva Granada.