Synthesis of N-6-alkylated adenosine derivatives

Abstract N 6-ablated adenosine can be synthesized by reduction of the corresponding carboxylic acid amides using Lm. Starting from 2′,3′-O-isopropylidene adenosine, N 6-ethyladenosine, N 6-propyladenosine, N 6-isobutyladenosine, N 6-benzyladenosine and N 6-furfuryladenosine were obtained in a three step procedure (acylation, reduction, deprotection).