Regenerative effect of basic fibroblast growth factor on periodontal healing in two‐wall intrabony defects in dogs

Shirakata Y, Taniyama K, Yoshimoto T, Miyamoto M, Takeuchi N, Matsuyama T, Noguchi K. Regenerative effect of basic fibroblast growth factor on periodontal healing in two-wall intrabony defects in dogs. J Clin Periodontol 2010; 37: 374–381. doi: 10.1111/j.1600-051X.2010.01539.x. Abstract Aim: The aim of the present study was to evaluate the effect of a basic fibroblast growth factor (bFGF) candidate treatment on periodontal healing in two-wall intrabony defects in dogs. Materials and Methods: Two-wall intrabony defects (5 × 5 × 5 mm) were created surgically on the distal and mesial sides of bilateral mandibular second and fourth premolars in four Beagle dogs. bFGF, enamel matrix derivative (EMD) and platelet-derived growth factor with β-tricalcium phosphate (PDGF/β-TCP) treatments, and sham-surgery (OFD) were rotated among the four defects in each animal, EMD and PDGF/β-TCP serving as benchmark controls. The animals were euthanized for radiographic and histologic evaluation at 8 weeks. Results: Bone formation was significantly greater in the bFGF group (4.11 ± 0.77 mm) than in the EMD (3.32 ± 0.71 mm; p<0.05) and OFD (3.09 ± 0.52 mm; p<0.01) groups. The EMD (4.59 ± 1.19 mm) and PDGF/β-TCP (4.66 ± 0.7 mm) groups exhibited significantly greater cementum regeneration with periodontal ligament-like tissue than the OFD group (2.96 ± 0.69 mm; p<0.01). No significant differences were observed between the bFGF and the PDGF/β-TCP groups in any of the histometric parameters. Conclusions: The candidate bFGF treatment supported periodontal regeneration comparable with that of established benchmarks: EMD and PDGF/β-TCP.