Catechol-Bisphosphonate Conjugates: New Potential Chelating Agents for Metal Intoxication Therapy
2004
In a quest for better chelating therapy drugs for the treatment of intoxication by Fe, Al, or actinides, two new series of mixed catechol-bisphosphonate through amide linkage were synthesized. Benzyl group was used as protecting group to avoid the breakage of amide by acid hydrolysis or imcomplete reaction in silylation-dealkylation using bromotrimethylsilane. 5 . Catechol ligand functional group is commonly found in the siderochromes which are low-molecular-weight compounds produced by microbes and involved in their cellular iron transports 6 . The catecholate anion is highly sensitive to oxidation, while amide
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