Study on security of oral vitamin K1 to newborn infants

objective: To study the security of oral dose of Vitamin K1 (Hereinafter referred to as VK1) given to normal newborn infants. Method: 128 cases of normal newborn infants, who randomly divided into two groups, orally took 2. 5 mg VK1 or took 5 mg VK1 within 1-12 hours separately when they were born. All 128 cases of normal newborn infants were checked by screening the activity of glucose-6-phosphate dehydrogenase (Hereinafter referred to as G-6-PD) with reagent paper method in the first three days and observed what happened to jaundice and other adverse drug reactions after taking VK1. Result: There was no severe jaundice and skin erythema occurred and there was no apparent minus effect occurred to the digestive system with taking VK1. Conclusion: It is security of oral VK1 to newborn infants with 2. 5 ~ 5 mg of oral VK1 in a short time to prevent the newborn infants from hemorrhagic diseases.