B-cell epitope of human melanoma antigen MAGE-A3 and application thereof

The invention relates to a preparation method and application of a B-cell epitope recombinant protein of human melanoma antigen MAGE-A3 protein. The invention discloses three B-cell epitope-containing polypeptides obtained by screening based on the full-length MAGE-A3 protein. The invention further discloses coded amino acids and nucleotide sequences of B-cell epitope-containing polypeptides. The invention also discloses application of B-cell epitope-containing polypeptides on prevention, treatment and diagnosis of MAGE-A3-positive tumors. The B-cell epitope recombinant protein of MAGE-A3 protein is very strong in immunogenicity and antigenicity, and the application prospect is good.