The association between serum uric acid level and heart failure and mortality in the early period of ST-elevation acute myocardial infarction ST yükselmeli akut miyokart enfarktüslü hastalarda ürik asit düzeyi ile erken dönem kalp yetersizliği ve mortalite arasindaki ilişki

Objectives: Uric acid (UA) is a strong marker of cardiovascular disease. Therefore, we aimed to determine the relationship be- tween serum UA levels and cardiovascular events in patients in the early period of their acute myocardial infarction. Study design: This retrospective study included 586 consecu- tive patients with ST-elevated myocardial infarction (STEMI) who were admitted to the hospital between March 2010 and February 2012. The study population was divided into two groups; the first group included hyperuricemic patients (n=107; uric acid level >6 mg/dl in women and >7 mg/dl in men), and the second group included patients with normal UA level (n=479). Multivariate analysis was used to demonstrate the predictive value of UA levels in groups. Results: Patients in the hyperuricemic group were older (me- dian 66 years vs. 60 years, p=0.001), and the ratio of female patients was higher (35.5% vs. 16.9%, p=0.001). Patients with hyperuricemia had a significantly higher incidence of in-hospi - tal cardiovascular mortality than the normal group (15.9% vs. 3.1%, p 6 hours and hy- peruricemia (hazard ratio (HR): 1.83, 95% confidence interval: 1.02-3.27; p=0.041) were found to be independent predictors of advanced heart failure. Hyperuricemia was found to be an independent predictor of in-hospital cardiovascular mortality in multivariate analyses (HR: 5.32, 95% confidence interval: 2.46- 11.49; p=0.001). Conclusion: This study showed that a high serum UA level is an independent predictor of cardiovascular mortality and mor- bidity during the in-hospital period of STEMI. ABSTRACT OZET