Reduced Clearance of Phenobarbital in Advanced Cancer Patients near the End of Life

Hirokazu Nakayama,Hirotoshi Echizen,Ryuichi Ogawa,Takao Orii,Toshiaki Kato

Reduced Clearance of Phenobarbital in Advanced Cancer Patients near the End of Life

2019

Hirokazu Nakayama
Hirotoshi Echizen
Ryuichi Ogawa
Takao Orii
Toshiaki Kato

Background and Objectives Little is known about the pharmacokinetics of phenobarbital in terminally ill cancer patients. We investigated whether phenobarbital clearance alters depending on the length of survival.

Keywords:

Anesthesia
Cancer
Chemistry
Phenobarbital
Pharmacokinetics
Oncology
Internal medicine
advanced cancer
terminally ill

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