A Method for Estimating Pulse Wave Amplitude Variability in children with Sleep Disordered Breathing

Sleep disordered breathing (SDB) is a common pediatric disorder, which results in increasing respiratory workload during sleep, restless night time sleep and excessive daytime sleepiness. It has significant negative effects on children with SDB on their physical growth and cognitive related developments. Chronic autonomic activation was suggested to be one of the possible key drivers causing cardiovascular structural changes in SDB children and increasing the risk of developing cardiovascular disease in their future. The aim of this study was to investigate the effect of SDB on autonomic activation changes in children, by analyzing the pulse wave amplitude (PWA) dynamics using a simple envelope estimation method extracting PWA from PPG signal.Children with SDB (n = 40) showed a significantly a wider dynamic distribution in PWA compare to matched controls (n = 40), which suggests a higher and stronger level of autonomic response in SDB children.In conclusion, the PWA dynamic is altered in children with SDB during sleep and indicate changes in autonomic activation.