Electrochemical sensing of L-ascorbic acid by using a glassy carbon electrode modified with a molybdophosphate film

Electrochemical sensing of L-ascorbic acid (AA) is reported based on the use of a redox-active molybdophosphate film on a glassy carbon electrode (GCE). Molybdophosphate is formed by reacting hydroxyapatite nanoparticles with sodium molybdate. The modified GCE can be utilized for detection of AA, typically at a working potential of 0.4 V (vs. Ag/AgCl). The GCE has a decreased overpotential and enhanced sensitivity (219 μA·mM−1·cm−2). Response is linear in the 1 μM to 1.5 mM AA concentration range, and the limit of detection is 4 nM. The selectivity of this sensor makes it a useful tool for accurate determination of AA in practical samples as shown for a vitamin C tablet and for spiked beverages.