Improved decoupling during symmetry-based C9-TOBSY sequences

We show that heteronuclear decoupling during symmetry-based C9 TOBSY sequences can be improved by using phase-alternating pulse sequences (XiX) instead of cw irradiation. The use of XiX sequences makes the optimization of the decoupling rf-field amplitude simpler and lowers the decoupling rf-field requirements to attain a comparable performance. A Floquet analysis of the first-order resonance conditions was used to determine the correct timing of the XiX sequence to avoid interference between the C sequence and the decoupling. The decoupling performance is analyzed analytically using Floquet theory and verified using numerical simulations as well as experimental results.