Low-dose aspirin in non-tubal IVF patients with previous failed conception: a prospective randomized double-blind placebo-controlled trial

Objective To analyze whether the administration of low-dose aspirin during IVF treatment improves the uterine blood flow and improves ongoing pregnancy rates for non–tubal factor IVF patients with previous failed conception. Design Prospective double-blind placebo-controlled trial. Setting University fertility clinic. Patient(s) Non-tubal IVF patients with previous failed conception. Intervention(s) Daily 100 mg aspirin or placebo throughout an IVF treatment with a long GnRH-agonist stimulation protocol. Main Outcome Measure(s) Ongoing pregnancy rate, pulsatility index of the uterine artery. Result(s) Of 169 patients, 84 were assigned to aspirin treatment and 85 to placebo treatment. In the aspirin group, 28 patients (35.4%) had an ongoing pregnancy, and in the placebo group, 26 patients (31.0%) had an ongoing pregnancy. Multilevel analyses showed that the pulsatility index of the uterine artery was not affected by aspirin or placebo treatment. Conclusion(s) Low-dose aspirin administration during IVF treatment does not improve pregnancy rates of non–tubal factor IVF patients with previous failed conception, and it does not affect the arterial uterine blood flow.