Favourable IGCCCG subgroups of stage II NSGCT patients may require less chemotherapy if TNM staging is included

4532 Background: When the IGCCCG prognostic factor analysis was performed there were few stage II cases included in this analysis of chemotherapy cases. Patients were not included from centres which used primary retroperitoneal lymph node dissection followed either by 2 courses of adjuvant chemotherapy or 3 courses at relapse. Primary surgery is the standard of care in North America but not in Europe where primary chemotherapy is used. To investigate this issue the impact of nodal (stage II) versus extra nodal (stage IV) metastases in each of the IGCCCG sub-groups has been examined in an audit of 447 patients treated in centres where chemotherapy rather than RPLND was primary management for stage 2 non-seminoma. Methods: Clinicians from 7 centres (St Barts, Oldchurch, Southend, Colchester, Ipswich, Norwich and Cambridge) have prospectively registered cases in a central data base at St Barts and notes review and follow up has been co-ordinated. Results: Between 1982 and 2002 447 patients were registered an...