Патоморфогенетические особенности геморрагической лихорадки с почечным синдромом в Дальневосточном регионе

On the basis of the analysis of lethal cases the hemorrhagic fever with nephritic syndrome, observed in Primorsky Krai and the Amur area, are determined features of pathological process at this infection in Far East region. It is shown, that basic pathogenetic path of the hemorrhagic fever with nephritic syndrome is system defeat of micro vessels, caused by expressed toxic properties of hantavirus during the period of virusemia. Thus hantavirus infection renders direct cytolytic action on endothelial cells. It is marked, that the destructive necrotic changes in target organs (especially in kidneys and lungs) carry not only secondary character owing to expressed hemodynamic frustration, but also are connected to direct action of a virus. The specific features of patho-morphology of the hemorrhagic fever with nephritic syndrome is the minimal expressiveness of cellular reaction peculiar to a typical inflammation in tissue that is caused by misbalance of inflammatory cytokines developing at this infection.