Palladium‐Catalyzed Cascade Cyclization of Allylamine‐Tethered Alkylidenecyclopropanes: Facile Access to Iodine/Difluoromethylene‐ and Perfluoroalkyl‐Containing 1‐Benzazepine Scaffolds.

The unprecedented palladium-catalyzed cascade cyclization of allylamine-tethered alkylidenecyclopropanes with an ethyl difluoroiodoacetate or perfluoroalkylated reagent is developed, providing facile access to a variety of synthetically and medicinally valuable iodine/difluoromethylene- and perfluoroalkyl-containing 1-benzazepine frameworks. These reactions exhibited good yields and functional group tolerance via a radical mechanism.